IDEA #54W9JK Enhanced Solubility and Stability of Vitamins Using Tryptophan-Containing Tripeptide Aggregates. 25A0025

Key Words: peptide formulation, self-assembly, vitamins, stabilization, solubilization The invention enhances the solubility and stability of vitamins, particularly riboflavin (Vitamin B2), in both solution and solid states. It achieves this under diverse environmental conditions, including varying humidity, temperature, and light levels, by leveraging the self-assembling properties of tripeptides such as WYK and WKY. The invention addresses several unmet needs in the pharmaceutical and nutraceutical fields: • Stability Enhancement: Vitamins often degrade rapidly under light and environmental stress, limiting their shelf life and efficacy. • Improved Solubility: Poor water solubility restricts the bioavailability of vitamins, reducing their effectiveness in formulations. • Cold Chain Reduction: By stabilizing vitamins at room temperature, this technology reduces dependency on cold storage, cutting logistics costs and making vitamins more accessible in low-resource settings.
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