IDEA #4EA54V Expansion of the naturally existing genetic alphabet to design new nucleic acid materials, termed Exteded Nucleosides and Nucleotides, Nucleic Acids (ENDN3A), to expand the chemical space of nucleic acids based materials and ligands. 24A0004

C. What is the purpose and utility of the invention in general terms? Use as much space as necessary. 1. Make all building block as a nucleoside, nucleotides, and phosphonamidites commercially available for R and D 2. Screen nucleosides for enzyme inhibitors in bacterial, cancer and other disease related cellular pathways 3. Design DNA/RNA objects with photonic, electronic properties 4. Antisense therapy 5. Cell permeability studies 6. microRNA therapeutics 7. Ligand designs 8. Drug discovery 9. Biocompatible supramolecules assemblies for biomedical applications 10. mRNA vaccine desings