Key Words:
bioadhesive, hydrogel, semi-degradable, oxidation, tissue adhesive, cellulose, injectable, hydrophobic, thermosensitive, thermogelation, annulus fibrosus, herniation, wound closure.
The invention is an injectable, thermoresponsive, semi-permanent hydrogel which gels in situ, and chemically bonds to exposed primary amines of extracellular matrix (ECM) proteins in mammalian tissues, thereby acting as a biological glue. Facile tunability of bulk mechanical and chemical properties through simple adjustments to constituent proportions and concentrations supports feasibility for the embodiment of a relatively broad range of applications. The use detailed here represents a proof-of-concept application as a surgical glue for dermal tissues and internal wound closure, but the material could be adapted for other clinical indications, such as a sealant for intervertebral disc herniations, a hemostatic device and as an embolic agent.
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