Key Words: quantitative phase imaging, polarization light microscope, birefringence optical histopathology, realtime imaging.
4C.
What is the purpose and utility of the invention in general terms?
This invention is about a new type of microscopy which can image both quantitative phase and birefringence of live cells and tissue specimens in real-time and label-free from single snapshots with intrinsic contrasts. Quantitative phase provides cell mass distribution and morphology. Birefringence provides the molecular organization order. The new invention provides real-time imaging capability only limited by the camera frame rate without any staining. The synergy of quantitative phase and birefringence is extremely valuable in cancer prognosis and developmental biology etc.
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