Stimulating Neural Regeneration by Regulating MAG Activity with Sialidase and Sialic Acid-Bearing Carriers
Myelin-associated glycoprotein (MAG) has been identified as a potent inhibitor of neural regeneration. In addition, MAG binding to neurons is sialic acid-dependent. This invention therefore includes sialic acid-bearing carriers (e.g. sugars, proteins, peptides, lipids and glycans) and sialic acid related enzymes (e.g. sialidase) that can be administered to reverse the inhibitory effect of MAG on neural growth. The products and compositions of this invention can be developed into therapies to stimulate neural regeneration after spinal cord injuries and for treating neurodegenerative disorders.
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