IDEA #3FO3S1 New Test-Systems For Detection Of Some Psychotropic Drugs And Technogenic Toxic Substances

NEW TEST(cid:2)(cid:2)SYSTEMS FOR DETECTION OOFF SOME PSYCHOTROPIC DRUGS AND TECHNOGENIC TOXIC SUBSTANCES LIFE SCIENCES • MEDICALRESEARCH Description Express(cid:2)tests are the most suitable method of fast and simple control of the presence of dangerous substances in out(cid:2)of(cid:2) laboratory conditions. Test is based on the indicator chemical reactions where the determined substances form the coloured products or dis(cid:2) colour the initial reagents. We developed some test(cid:2)systems for determination of the fol(cid:2) lowing psychotropic compounds: • opiates, • hemp (cannabinoides), • barbiturates, • 1,4 (cid:2) benzodiazepines, • phenothiazines. These tests can be used for analyses the initial products and medicinal forms. The test methods for detection and semiquantitative determi(cid:2) nation of: • active chlorine in water and • nitrates in fruits and vegetables have been developed too. The test methods for determination of the • heavy metals traces in the potable and natural waters are being developed also. Innovative Aspect and Main Advantages The proposed tests were based on the new indicator reactions of complexation (opiate(cid:2), barbiturate(cid:2) and metal(cid:2)tests), of the diazotation and azocoupling (cannabis(cid:2) and nitrate(cid:2)tests) as well as of the oxidation condensation (phenothiazine(2)(cid:2)test). The paper, polymethylmethacrylate, polyurethane foam, glass as the substrates were used. Some test(cid:2)systems were designed as indicator papers, mark(cid:2) ers, spray or dropping bottles. (Photo). It takes no more than 2(cid:2)3 min. for testing which is accompa(cid:2) nied by colour change for: • opiate from lilac to blue, • hemp from colorless to red, • barbiturates from red(cid:2)violet to yellow, • phenothiazines from colorless to violet, • 1,4(cid:2)benzodiazepines – the preservation of blue colour. Test selectivity checking has shown that the pharmaceuticals of other groups give negative results under the chosen condi(cid:2) tions. Test positive result should be re(cid:2)checked in the lab con(cid:2) ditions. The test detection limits for the pharmaceutical drugs are being below several tenth of mg powder in a solution drop. The high sensitivity, reliability, simple carrying out and low cost are the main advantages of the developed tests. The obtained analytical effect may be observed visually or by means of portable instruments. Fig.1 “Opiate(cid:2)test” is realized in the form of indi(cid:2) cator papers, markers and sprayers. Areas ooff Application The development of new fast chemical methods (tests) for out(cid:2) of laboratory detection of extremely dangerous substances, in particular, technogenic toxic and physiologically active sub(cid:2) stances may be a matter of interests for the firms producing materials for chemical testing, chemical reagents and other materials of "fine chemicals". The use of the express(cid:2)tests will favour the struggle against non(cid:2)medical use and expansion of some pharmacological psy(cid:2) chotropic drugs among the population due to their timely detection. Stage ooff Development The some developed express(cid:2)tests were covered by patents of Ukraine; others indicator reactions are being studied. Contact Details Research(cid:2)and(cid:2)Production complex “Institute for Single Crystals” of National Sciences Academy of Ukraine Contact person: Tatyana Ivanovna, Ph.D., Senior researcher Address: 60 Lenin Avenue, Kharkov, 61001, Ukraine Теl: (38057) 341 01 06 Fax: (3803722) 340 93 43 E(cid:2)mail: ivkova@isc.kharkov.com INNOVATIVETECHNOLOGY OPPORTUNITIES FROM THE STCU 127