IDEA #5S028O New Programmable 3-Axis Piezoelectric Nanomanipulator With Ultra-Low Drift For Cells Technologies

THE SCIENCE AND TECHNOLOGY CENTER IN UKRAINE NEW PROGRAMMABLE 3-AXIS PIEZOELECTRIC NANOMANIPULATOR WITH ULTRA-LOW DRIFT FOR CELLS TECHNOLOGIES Description Robotic micromanipulators are used for demanding bio- tech applications such as Patch Clamp (holding and posi­ tioning a cell), IVF (in-vitro fertilization), and cell cloning, as well as in the semiconductor integrated circuits industry - all growing markets. LILEYA's PSF-3 IVF is a state-of-the-art 3-axis nanomanipulator system based on advanced piezoelectric rotary motor, integrated with a multifunctional programmable controller including 46 operations. When the motor is deenergized, it provides an automatic solid brake on movement, with almost unde­ tectable backlash and drift. It works by converting the rotary motion of an advanced piezoelectric motor (fitted onto each axis of the nanomanipulator) into linear motion. A combination of high torque, variable speed and high angular resolution enables the piezoelectric motor to be used in either continuous or stepper mode. These charac­ teristics facilitate a smooth transition, without degrada­ tion in intrinsic performance, from an angular step of less than 5 μrad to continuous motion, and a range of angular velocities, from 5 μrad/sec up to 60 rev/min. This trans­ lates into a linear resolution of 0.4 nm and a linear range of velocities from 0.4 nm/sec to 500 μπι/sec for each axis of the PSF-3IVE Additional benefits of the PSF-3 IVF design include the elimination of heat dissipation, ultra- low electrical noise and low supply voltage (12 VDC), which together make the PSF-3 IVF ideal for very sensi­ tive applications. Innovative Aspect and Main Advantages PSF-3 IVF combines extremely high resolution (0.4 nm), long term stability (drift less than 2 nm/hour @ 20°C) and long travel (10 mm). The "Stick/Slip" is one of the major factors, which limits nanometer resolution and hence the performance of traditional nanopositioners/manipulators. The PSF-3 IVF overcomes the stick/slip effect using the unique combination of the piezoelectric motor and control system. Any angular position of the rotor is locked by the self decelerating torque of the motor. The same force locks the whole friction system of the nanomanipulator. To limit the effect of any jump when initiating motion the unlock­ ing process must occur almost instantaneously (within ΙΟ-ΙΟΟμβεΰ). PSF-3 IVF has been designed to implement a step formation within 2-10 μsec/μrad. This timing results in an angular step of the motor in the nanometer range, which translates immediately into an equivalent lin­ ear step eliminating measurable static friction effects. Areas of Application LILEYA's advanced Nano-Manipulator technology is designed to meet a variety of positioning needs for the sci­ entific, biotechnology, medical, semiconductor and indus­ trial markets. It is suitable for applications such as: patch clamp experiments on cells in culture, microinjection into cells, cell imaging, cellular and material handling, IVF fer­ tilization and sterility treatments, DNA cloning experi- Fig. 2. Nanomanipoulator Fig. 3. Nanomanipulator PSF- PSF-3 IVF -H 3 IVF ments, extra cellular recording, intracellular recording, cytopathology, precision robotic applications, MRI-guided robotic surgery applications, integrated circuits applica­ tions, IС mask generation and alignment, IС lithography IС wafer measurements, fiber optic assembly and align­ ment, laser production, Ε-beam control for IC's, ion beam control for IC's, read-write heads for recording tape and CD's, storage media applications. Stage of Development LILEYA's unique designs are protected by: United States Patent MICROMANIPULATOR, Application Serial No.#2005/0023930 - Canadian Patent Application MICROMANIPULA­ TOR, number 2527502 - Russia Patent MICROMANIPULATOR No.2041480 - UA Patent MICROMANIPULATOR No.2002064866 LILEYA builds systems with superior high performance characteristics and it can produce 100-400 systems per year Contact Details Contact person: Sergii Petrenko Small Scientific Production Enterprise LILEYA Ltd. Contact address: Kiev-03150, Predslavinskaya 39, off. 511 Tel/Fax: (380-44) 502-1376 Mob.: 8(067) 918-32-68 E-mail: tyll@naverex.kiev.ua Web-site: www.piezomotor.com.ua