IDEA #323FV9 Method Of Production Of Spirulina Biomass With Elevated C-Phycocyanin Content To Enhance The Immune System

METHOD OOFF PRODUCTION OOFF SPIRULINA BIOMASS WITH ELEVATED CC(cid:2)(cid:2)PHYCOCYANIN CONTENT TTOO ENHANCE THE IMMUNE SYSTEM Description LIFE SCIENCES • BIOLOGICALMATERIALS Production of Spirulina biomass enriched with an immunomodulator c(cid:2)phycocyanin administrates by the culti(cid:2) vation of Spirulina platensis, strain G(cid:2)27. This mutant strain is able to accumulate up to 36% of phycocyanin in dried biomass while its parental strain contains no more that 15% of dried biomass. The lack of thick polysaccharide sheath on G(cid:2)27 fil(cid:2) aments and their enlarged length makes Spirulina biomass harvest and the washing easier and more effective upon the filtration through wire(cid:2)gauze. It was shown that the biomass of G(cid:2)27 strain is not toxic. Model experiments have shown that the feeding of the rats having experimental radiation lesion or an anemia with G(cid:2)27 strain biomass led to significant correc(cid:2) tion of both pathological processes. Innovative Aspect and Main Advantages A mutant of Spirilina platensis with genetically determined c(cid:2) phycocyanin overproduction has been obtained. This feature of mutant strain seems to be exceptionally stable during recent 15 years. The cultivation of G(cid:2)27 strain instead of its parental strain leads to the increase c(cid:2)phycocyanin yield because of its high(cid:2) er content in biomass as well as the optimization of the culti(cid:2) vation conditions. The c(cid:2)phycocyanin content in G(cid:2)27 strain biomass exceeds that index in a prototype strain up to 1.7(cid:2)2.9 folds under the same cultivation conditions. G(cid:2)27 strain long trichomes (fivefold longer than that of proto(cid:2) type strain) make the process of biomass collecting and wash(cid:2) ing by means of filtering significantly easier. Areas ooff Application The Spirulina platensis strain G(cid:2)27 with enhanced content of an immunomodulator c(cid:2)phycocyanin might be used for the production of the health prophylactic food formulas and cos(cid:2) metic stuff. Stage ooff Development Development phase – laboratory tested Contact Details Odessa Mechnikov National University Contact person: Sofia Karakis Address: Dvoryanskaya St., 2, Odessa, Ukraine, 65026 Telephone: +38(048)7264426 Email: ibrown@te.net.ua Pic.1 Spirulina platensis (Nordst.) Geitl. mutant G(cid:2)27 strain. Pic.2. Spirulina platensis (Nordst.) Geitl. wild strain (pro(cid:2) totype). Pic.3. Liquid cultures of Spirulina platensis G(cid:2)27 mutant strain and wild strain (prototype) (left – mutant strain G(cid:2) 27, right – wild strain). INNOVATIVETECHNOLOGY OPPORTUNITIES FROM THE STCU 121