IDEA #4BRP9K Electrodynamic Introscopy

ELECTRODYNAMIC INTROSCOPY LIFE SCIENCES • MEDICALRESEARCH Description The developed technology (cid:2) Electrodynamic Introscopy (EI) – opens a new direction of functional tomographic imaging. EI is based on the high(cid:2)resolution (< 1mm) scanning of an area of interest with extremely low(cid:2)intensive broadband electromag(cid:2) netic field. The obtained multiparameter image chains are processed in real time with the aid of spectral, statistic and original methods of analyses. Thus, EI enables in vivo, nonin(cid:2) vasive/nonioni(cid:2)zing high(cid:2)quality visualization&monitoring of the 3D dynamics of integral electrobiochemical parameters at tissue, cellular and sub(cid:2)cellular levels in norm and pathology. Its upmost application is earlier cancer diagnosis and directed therapy, but EI can be also effectively applied for solving numerous pressing biomedical problems. Innovative Aspect and Main Advantages The EI technology differs from known high(cid:2)informative sys(cid:2) tems of functional imaging (first of all (cid:2) PET) by its: 1. No ionizing radiation; 2. Sound cost/effectiveness (1(cid:2)2 orders less), simple and fast investigation procedure; 3. Fundamentally different set of measurement parameters (which specifically made it firstly possible to in vivo monitor calcium waves of intercellular communication). EI also ensured discovery of a novel class of spatiotemporal electro(cid:2) physiological phenomena, which may be specifically used as basically new tumor diagnostic criteria and input biofeedback data for developing effective methods of the directed therapy. For example, the EI technology makes it firstly possible to reveal /monitor areas of: • mitochondrial abnormalities (see Fig.2, 3. Melanomas and nevuses have been chosen as demonstrative objects because of their clearness); • aerobic and anaerobic, i.e. malignant, type of tissue respi(cid:2) ration, identify true tumor geometry with its microenviron(cid:2) ment and preclinical distant micrometastasizes (< 1 mm)(see Fig. 2, 4). Areas ooff Application Practically all medical disciplines, specifically: oncology (cid:2) ear(cid:2) lier diagnostics and targeted therapy (breast and skin can(cid:2) cers, proctology, gynaecology); inflammatory processes; mito(cid:2) chondrial diseases; pain visualization; real(cid:2)time investigations of the organism response to various therapeutic/environ(cid:2) mental factors; cosmetology. Stage ooff Development Late stage (prototype of industrial sample). A demonstration EI setup is available. Fig.1. General view of the portable EI complex for investigation of external tissues Fig.2. Photo of malignant melanoma region (impress of the scan(cid:2)head 32?64mm can be seen). Fig.3. An EI pattern: mitochondrial abnormalities at the same region (the tumor visible boundary is marked with dotted line). Fig.4. The same region. Another EI(cid:2) pattern (intercellular level): metastatic process at the tumor microenviron(cid:2) ment and distant areas (obtained in response to hypoxic test). Contact Details Centre of Biomedical Electroengineering, Kiev, Ukraine. Yuriy F. Babich, Ph.D. 03049, Kurska12Б/22, Kiev, Ukraine E(cid:2)mail: b62@rambler.ru, babich@ua.fm, Tel/Fax: (+38044)(cid:2)2453631 INNOVATIVETECHNOLOGY OPPORTUNITIES FROM THE STCU 137