ELECTRODYNAMIC INTROSCOPY
LIFE SCIENCES • MEDICALRESEARCH
Description
The developed technology (cid:2) Electrodynamic Introscopy (EI) –
opens a new direction of functional tomographic imaging. EI is
based on the high(cid:2)resolution (< 1mm) scanning of an area of
interest with extremely low(cid:2)intensive broadband electromag(cid:2)
netic field. The obtained multiparameter image chains are
processed in real time with the aid of spectral, statistic and
original methods of analyses. Thus, EI enables in vivo, nonin(cid:2)
vasive/nonioni(cid:2)zing high(cid:2)quality visualization&monitoring of
the 3D dynamics of integral electrobiochemical parameters at
tissue, cellular and sub(cid:2)cellular levels in norm and pathology.
Its upmost application is earlier cancer diagnosis and directed
therapy, but EI can be also effectively applied for solving
numerous pressing biomedical problems.
Innovative Aspect and Main Advantages
The EI technology differs from known high(cid:2)informative sys(cid:2)
tems of functional imaging (first of all (cid:2) PET) by its:
1. No ionizing radiation;
2. Sound cost/effectiveness (1(cid:2)2 orders less), simple and fast
investigation procedure;
3. Fundamentally different set of measurement parameters
(which specifically made it firstly possible to in vivo monitor
calcium waves of intercellular communication). EI also
ensured discovery of a novel class of spatiotemporal electro(cid:2)
physiological phenomena, which may be specifically used as
basically new tumor diagnostic criteria and input biofeedback
data for developing effective methods of the directed therapy.
For example, the EI technology makes it firstly possible to
reveal /monitor areas of:
• mitochondrial abnormalities (see Fig.2, 3. Melanomas and
nevuses have been chosen as demonstrative objects because
of their clearness);
• aerobic and anaerobic, i.e. malignant, type of tissue respi(cid:2)
ration, identify true tumor geometry with its microenviron(cid:2)
ment and preclinical distant micrometastasizes (< 1 mm)(see
Fig. 2, 4).
Areas ooff Application
Practically all medical disciplines, specifically: oncology (cid:2) ear(cid:2)
lier diagnostics and targeted therapy (breast and skin can(cid:2)
cers, proctology, gynaecology); inflammatory processes; mito(cid:2)
chondrial diseases; pain visualization; real(cid:2)time investigations
of the organism response to various therapeutic/environ(cid:2)
mental factors; cosmetology.
Stage ooff Development
Late stage (prototype of industrial sample).
A demonstration EI setup is available.
Fig.1. General view of the portable EI complex for
investigation of external tissues
Fig.2. Photo of malignant melanoma region (impress of
the scan(cid:2)head 32?64mm can be seen).
Fig.3. An EI pattern: mitochondrial abnormalities at the
same region (the tumor visible boundary is marked with
dotted line).
Fig.4. The same region. Another EI(cid:2) pattern (intercellular
level): metastatic process at the tumor microenviron(cid:2)
ment and distant areas (obtained in response to hypoxic
test).
Contact Details
Centre of Biomedical Electroengineering, Kiev, Ukraine.
Yuriy F. Babich, Ph.D.
03049, Kurska12Б/22, Kiev, Ukraine
E(cid:2)mail: b62@rambler.ru, babich@ua.fm,
Tel/Fax: (+38044)(cid:2)2453631
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